HORDB

ID: hor001776
Uniprot ID: Q9ESQ9
Protein name: Neuropeptide RFRP-1
Gene name: Npvf
Organism: Rattus norvegicus (Rat)
Family: FARP (FMRFamide related peptide) family
Source: animal
Expression: Isoform 1 is expressed at high levels in the hypothalamus and eye. Isoform 2 is specifically expressed in a region between the dorsomedial hypothalamic and ventromedial hypothalamic nuclei.
Disease: NA
Comments: NA
Taxonomy: Rattus (genus), Murinae (subfamily), Muridae (family), Muroidea, Myomorpha (suborder), Rodentia (order), Glires, Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005102 signaling receptor binding
GO BP: GO:0007218 neuropeptide signaling pathway; GO:0032277 negative regulation of gonadotropin secretion
GO CC: GO:0005576 extracellular region

Sequence: VPHSAANLPLRF
Length: 12(83-94)
Propeptide: MEIISSKRFILLTLATSSFLTSNTLCSDELMMPHFHSKEGYGKYYQLRGIPKGVKERSVTFQELKDWGAKKDIKMSPAPANKVPHSAANLPLRFGRNIEDRRSPRARANMEAGTMSHFPSLPQRFGRTTARRITKTLAGLPQKSLHSLASSELLYAMTRQHQEIQSPGQEQPRKRVFTETDDAERKQEKIGNLQPVLQGAMKL
Signal peptide: MEIISSKRFILLTLATSSFLTSNTLC
Modification: T12 Phenylalanine amide
Glycosylation: NA
Mutagenesis: NA

Function: Acts as a potent negative regulator of gonadotropin synthesis and secretion
Mechanism: NA
Cross BBB: NA
Target: Npffr1
Target Unid: Q9EP86
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor001776_AF2.pdb

hor001776_ESM.pdb

Mass:	151793	Formula:	C61H96N18O15
Absent amino acids:	CDEGIKMQTWY	Common amino acids:	ALP
pI:	10.55	Basic residues:	2
Polar residues:	2	Hydrophobic residues:	6
Hydrophobicity:	25	Boman Index:	-914
Half-Life:	100 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	105.83
Instability Index:	5731.67	Extinction Coefficient cystines:	0
Absorbance 280nm:	0